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Updated: May 11, 2026

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脑脊液蛋白质学识别了自体主导阿尔茨海默病的早期变化

Yuanyuan Shen1, Jigyasha Timsina1, Gyujin Heo1

  • 1Department of Psychiatry, Washington University, St. Louis, MO 63110, USA; NeuroGenomics and Informatics, Washington University, St. Louis, MO 63110, USA.

Cell
|September 27, 2024
PubMed
概括

这项研究确定了137种脑脊液蛋白,显示出自体主导性阿尔茨海默病 (ADAD) 突变载体的明显变化,其中包括8种早期生物标志物. 在传统标志物出现之前,六种蛋白质的子组有效地区分疾病的进展.

关键词:
索马斯 扫描自体主导性阿尔茨海默病微质细胞线粒体损伤神经退行症神经元死亡蛋白质组学伪轨迹分析

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