基于冲击的呼气采样用于物质监测:一项前性试点研究 (Drugxhale)
Lutea A A de Jong1, Erik J H Olyslager1, Jan A Wieferink1
1Department of Clinical Pharmacy, Expert Centre Gelre-iLab, Gelre Hospitals, PO Box 9014, 7300 DS Apeldoorn, The Netherlands.
Journal of breath research
|September 27, 2024
概括
呼吸分析为药物监测提供了一个非侵入性的替代方案,显示了与尿液测试的适度一致. 这种方法可以在临床环境中补充或取代传统的尿液药物检测.
科学领域:
- 分析化学 分析化学
- 法医毒理学 法医毒理学
- 临床化学 临床化学
背景情况:
- 尿液药物检测是监测药物摄入的标准,但面临着诸如改和隐私问题等挑战.
- 对替代矩阵的需求推动了对更少侵入性和更安全的药物检测方法的研究.
- 呼吸分析为检测近期药物使用提供了一个有希望的非侵入性替代方案.
研究的目的:
- 评估基于冲击的呼吸采样设备 (Breath Explorer®) 的有效性,作为尿液药物监测的替代方案.
- 评估呼吸分析与临床环境中的传统尿液检测的可行性和一致性.
- 探索呼吸分析作为物质监测的补充诊断工具的潜力.
主要方法:
- 一项潜在的试点研究使用呼吸探险器®设备进行呼吸采样.
- 使用经过验证的32组分液体染色学-并联质谱法 (LC-MS/MS) 方法分析呼吸样本.
- 将呼吸测试结果与尿液药物测试结果进行比较,计算卡帕值以达成一致.
主要成果:
- 对于32个分析样本的平均恢复率在自动化和手动处理呼吸器设备的39.5%至55.4%之间.
- 呼吸分析显示,与尿液分析 (kappa = 0.5) 有适度的一致性,表明其作为补充工具的潜力.
- 在呼吸样本中观察到甲 (70%的甲,100%的EDDP) 和6-单甲 (90%) 的高检测率.
结论:
- 使用Breath Explorer®设备进行呼吸分析是一种方便,非侵入性,易于使用的药物监测方法.
- 该方法显示出可能补充或取代基于尿液的药物测试,因为减少了改风险和自动抽样能力.
- 需要对更大的队列进行进一步的研究,以充分建立呼吸分析作为物质监测的可靠临床诊断工具.
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