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长期太极拳与有氧运动对帕金森病患者抗氧化活性和认知功能的影响

Chia-Liang Tsai¹, Chung-Yao Chien², Chien-Yu Pan³

¹Institute of Physical Education, Health and Leisure Studies, National Cheng Kung University, Taiwan; Department of Psychology, National Cheng Kung University, Taiwan.

Behavioural brain research

|September 27, 2024

概括

长期有氧运动 (AE) 和太极拳运动 (TCE) 可能有助于减少氧化应激,并改善帕金森病 (PD) 的认知功能. 在保持抗氧化剂水平和认知表现方面,AE显示出比TCE更大的好处.

科学领域:

神经科学是一个神经科学.
运动生理学运动生理学
生物化学生化学

背景情况:

氧化应激失衡与帕金森病 (PD) 的进展有关.
运动可以调节PD患者的氧化应激和认知功能.
了解运动对抗氧化剂和认知的影响对于PD管理至关重要.

研究的目的:

比较长期有氧运动 (AE) 和太极拳运动 (TCE) 对PD抗氧化剂和认知的影响.
调查生化标记物变化和认知表现改变之间的关联.
评估运动作为PD的治疗策略.

主要方法:

61名PD患者随机分为AE,TCE或对照组12周.
在干预前和后的血液样本中分析了抗氧化剂标记物 (8-OHdG,CAT,GSH,GSH-Px,GSSG,SOD,UA).
使用迷你精神状态检查 (MMSE) 评估认知功能.

主要成果:

在PD患者中,AE增加了catalase (CAT) 和glutathione (GSH) 水平,并降低了尿酸 (UA).
TCE增加了GSH水平.
对照组显示超氧化物脱酶 (SOD) 活性降低和MMSE得分.
AE组在MMSE和GSH/UA水平的变化之间显示出显著的相关性.

结论:

长期的AE和TCE是减少氧化损伤和保持PD认知功能的潜在策略.
AE表现出比TCE更显著的好处.
研究结果支持运动作为PD的补充疗法,特别是在早期阶段.

关键词:

具有抗氧化活性的抗氧化剂.认知认知是一种认知.运动运动运动.氧化应激是一种氧化应激.帕金森病是帕金森氏症的一种疾病.

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