通过由捐赠者获得的无细胞DNA检测来自捐赠者的移植后淋巴增殖性疾病的检测
Mia Wungnema1, Madelaine Hack2, Evgeniya Vaskova3
1Wy'east Pathway, Northwest Native American Center of Excellence, Portland, Oregon, USA.
概括
捐赠者衍生的无细胞DNA (dd-cfDNA) 在移植患者中检测到高水平,这表明了早期的移植后淋巴增殖性疾病 (PTLD). 这一发现使得迅速治疗,导致完全缓解和保存功能.
科学领域:
- 移植免疫学 移植免疫学
- 在瘤学瘤学.
- 分子诊断学 分子诊断学
背景情况:
- 移植后淋巴增殖性疾病 (PTLD) 是器官移植后的一种严重并发症.
- 诊断通常依赖于非特异性症状或移植器官功能障碍.
- 常规监测通常侧重于整体移植的拒绝.
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