在接受血造干细胞移植 (HSCT) 的血液恶性病患者中进行同行支持干预:STEPP概念验证试验
Hermioni L Amonoo1, Michelle Guo2, Emma P Keane3
1Department of Psychosocial Oncology and Palliative Care, Dana-Farber Cancer Institute, Boston, Massachusetts; Department of Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.
Transplantation and cellular therapy
|September 27, 2024
概括
像STEPP这样的同行支持计划可以改善血造干细胞移植 (HSCT) 患者的结果. 反改进了通过电话交付的干预,突出了共享经验的价值,并解决了参与障碍.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 移植医学 移植医学
- 患者支持计划 患者支持计划
背景情况:
- 同行支持干预措施有望改善癌症护理中患者报告的结果.
- 目前缺乏专门针对造血干细胞移植 (HSCT) 患者的结构化同行支持计划.
- 现有的支持往往无法满足HSCT接受者的独特需求.
研究的目的:
- 完善支持移植体验与同行计划 (STEPP),为HSCT患者提供手动,电话交付的同行支持干预.
- 收集患者的定性反,以确定促进者和阻碍参与STEPP干预的障碍.
- 为未来的STEPP代提供信息,以改善患者的治疗结果.
主要方法:
- 一个单臂,概念验证试验,涉及成年患者接受异构或自身的HSCT.
- 参与者接受了一个结构化的,五次会议的,通过电话交付的同行支持干预 (STEPP).
- 进行了半结构化的定性退出访谈,并使用快速分析方法进行分析,以评估患者的反.
主要成果:
- 在37名符合条件的患者中,有25人被录取;20人完成了干预和面试.
- 参与者重视了关于移植过程和处理临床信息的讨论.
- 促进者包括积极的初始经验;障碍涉及住院期间的后勤挑战和不匹配的同行导师档案.
结论:
- 接受HSCT的患者报告了结构化,电话交付的STEPP干预措施的积极经验.
- 患者的意见和计划结构对于HSCT有效的同行支持至关重要.
- 结果将指导未来的试验,以加强STEPP并改善HSCT接受者的结果.
相关概念视频
01:22Bone Marrow Sampling and Transplants
313
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
313
01:21Stem Cell Therapy for Tissue Regeneration
4.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.0K
01:01Regulation of Hematopoietic Stem Cells
3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
01:16Kidney Transplant III: Nursing Management
3
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
3
01:19Multipotency of Hematopoietic Stem Cells
3.0K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.0K