在患有症状良好控制的喘儿童中,强迫呼气体积在1秒内的变化
Nicole Filipow1, Stephen Turner2,3, Helen L Petsky4
1Great Ormond Street Institute of Child Health, University College London, London, UK.
Thorax
|September 27, 2024
概括
在患有喘的儿童中,螺旋计的变异性很大. 对于喘管理的临床决策应该优先考虑症状,而不是精神测量变化.
科学领域:
- 儿科肺病学 儿科肺病学
- 呼吸系统医学 呼吸系统医学
- 临床试验 临床试验
背景情况:
- 螺旋计对于监测儿童喘至关重要.
- 了解螺旋计测量测量的随时间变化对于精确的喘管理至关重要.
- 目前对控制良好的儿科喘中FEV1变异性的理解有限.
研究的目的:
- 为了确定强迫呼吸量在1秒内 (FEV1) 的变化,在患有症状控制良好的喘的儿童中.
- 为了比较三个方法来表达FEV1在3个月间隔的变化:预测FEV1% (FEV1%),FEV1z-score (FEV1z) 和变化条件z-score (Zc).
主要方法:
- 来自五项儿科喘研究的纵向数据的分析.
- 包括FEV1测量在6个月或12个月的3个月间隔进行.
- 计算FEV1%,FEV1z和Zc的协议极限以表达变化.
主要成果:
- 在控制喘期间,共有881名儿童提供了3338次FEV1测量.
- 对于FEV1% (-20至+21) 和FEV1z (-1.7至+1.7) 观察到广泛的协议范围.
- 有条件的z-score (Zc) 显示出更窄的一致边界 (-2.6到+2.1),并且受回归到平均或更年轻年龄的影响较小.
结论:
- 在症状控制良好的儿童中,对联FEV1测量显示出显著的可变性.
- 儿童喘治疗决策应主要依赖于症状评估.
- 单独的螺旋测量变化可能不是调整喘治疗的可靠指标,在得到良好控制的情况下.
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