大脑衰老和与年龄有关的痴呆症的机制,特征和治疗方法
Shiyun Jin1, Wenping Lu2, Juan Zhang3
1Department of Neurology, The First Affiliated Hospital of USTC, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China; Anhui Province Key Laboratory of Biomedical Aging Research, University of Science and Technology of China, Hefei 230027, China; Department of Anesthesiology, the Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China; Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, Hefei 230601, China.
了解与年龄相关的痴呆症 (ARD) 生物标志物和治疗策略对于早期发现和干预至关重要. 本综述对ARD生物标志物进行了分类,并总结了对抗大脑衰老的有希望的治疗方法.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 生物标志物发现发现
背景情况:
- 与年龄相关的认知衰退和痴呆症带来了重大的健康和社会经济挑战,特别是在快速增长的老年人口中.
- 尽管在痴呆症治疗方面取得了有限的临床突破,但最近在了解与年龄相关的痴呆症 (ARD) 机制方面的进展为治疗提供了新的希望.
研究的目的:
- 审查和分类在不同疾病进展阶段的ARD生物标志物的最新发现.
- 系统地总结有前途的治疗方法,以预防或减缓ARD在多个生物层面.
主要方法:
- 将ARD生物标志物的分类分为四个阶段:健康的大脑,临床前,轻度认知障碍和痴呆症.
- 对针对基因组,表观基因组,有机体,细胞和生物体的治疗策略进行系统审查.
主要成果:
- 在认知衰退的各个阶段识别和分类ARD的关键生物标志物.
- 针对ARD的各种治疗干预措施的摘要,从基因到生物水平,用于ARD.
结论:
- 早期预防和检测对于管理大脑衰老和ARD至关重要.
- 结合各种治疗方法的多模式干预策略对未来的ARD管理具有前景.
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