可解释生物学用于改进精准医学疗法:人工智能不够
1Division of Orthopaedics, Osteoarthritis Research Program, Schroeder Arthritis Institute, and Data Science Discovery Centre for Chronic Diseases, Krembil Research Institute, University Health Network, Toronto, ON, M5T 0S8, Canada; Departments of Medical Biophysics and Computer Science, and Faculty of Dentistry, University of Toronto, Toronto, ON, Canada; Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia.
Best practice & research. Clinical rheumatology
|September 27, 2024
概括
将多学科数据与人工智能 (AI) 整合在一起,对于推进精准医学至关重要. 高质量的数据和计算生物学工作流对于开发可靠的人工智能模型以以患者为中心的诊断和治疗至关重要.
科学领域:
- 计算生物学是一种计算生物学.
- 生物信息学是一种生物信息学.
- 精准医学是一门精准的医学.
背景情况:
- 复杂的疾病是由遗传学,生活方式和环境因素之间的相互作用造成的.
- 高通量生物化学试验产生了大量的多omics数据集,改变了生物假设测试和患者治疗.
- 当前的数据整合和分析方法难以有效管理复杂的生物和临床信息.
研究的目的:
- 突出整合多学科数据,本体学和注释的必要性,以了解复杂疾病.
- 强调人工智能 (AI) 和整合计算生物学在推进精准医学中的作用.
- 强调高质量,精心策划的数据对于开发可靠的人工智能模型和加速翻译研究的重要性.
主要方法:
- 系统地整合和分析多学科数据集,本体学和各种注释.
- "大数据"分析,人工智能和集成计算生物学工作流程的应用.
- 利用光学和生物化学测试技术的进步 (测序,质谱,成像).
- 使用数据挖掘,机器学习,图形理论和先进的可视化技术.
主要成果:
- 通过有效地整合多学科数据和人工智能,可以通过识别生物标志物和创建可解释的患者模型来改善疾病的理解和治疗.
- 计算分析有助于识别诊断,预后和预测生物标志物,了解药物机制,并优化患者选择.
- 将计算预测与生物实验交织在一起,可以加速生物和临床相关的发现.
结论:
- 高质量,精心策划的数据门户对于翻译研究,生物标志物发现和药物开发至关重要.
- 准确和全面的数据集和生物网络对于精准医学计算模型的可靠性至关重要.
- 综合计算生物学和人工智能之间的协同作用有望通过个性化治疗来提高患者的治疗结果和生活质量.
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