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Updated: Jun 11, 2025

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
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使用氨基基修饰剂的核酸的水性兼容后合成柱状结合

Jagandeep S Saraya1, Scott R Sammons1, Derek K O'Flaherty1

  • 1Department of Chemistry, University of Guelph, 50 Stone Rd E, Guelph ON, N1G 2 W1, Canada.

Chembiochem : a European journal of chemical biology
|September 27, 2024
PubMed
概括

我们开发了一种简单的,以水为基础的方法,用于将分子连接到核酸. 与其他合成方法相比,这种柱式技术可以改善净化和回收,从而实现增强的DNA功能.

关键词:
氨基酸链接 氨基酸链接核酸结合的核酸结合方式胺酸的酸链接固体支结合的结合方式

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Amines to Amides: Acylation of Amines01:19

Amines to Amides: Acylation of Amines

Various carboxylic acid derivatives (such as acid chlorides, esters, and anhydrides) can be used for the acylation of amines to yield amides. The reaction requires two equivalents of amines. The first amine molecule functions as a nucleophile and attacks the carbonyl carbon to produce a tetrahedral intermediate. This is followed by the loss of the leaving group and restoration of the C=O bond.
Next, the second equivalent of amine serves as a Brønsted base and deprotonates the quaternary...
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