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Updated: Jun 11, 2025

Preparation and Delivery of Protein Microcrystals in Lipidic Cubic Phase for Serial Femtosecond Crystallography
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小分子激动剂结合的三角类阿片类受体-Gi复合体的冷-EM结构使得发现有偏见的化合物成为可能

Lin Cheng1,2, Zhuang Miao1, Sicen Liu1,3,4

  • 1Department of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Nature communications
|September 27, 2024
PubMed
概括

用冷EM确定了三角类阿片类受体 (δOR) 结构,揭示了对其激活和信号的洞察力. 这项研究链接 δOR.

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