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原子级应变工程的原子分辨率Pt集群超越自然酶

Ke Chen¹, Guo Li², Xiaoqun Gong³

¹Tianjin Key Laboratory of Brain Science and Neural Engineering, Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China.

Nature communications

|September 27, 2024

概括

在金生物催化剂上的原子工程集群表现出卓越的类似酶的活性,显著提高了用于诊断和治疗干预的催化效率.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
生物催化剂是一种生物催化剂.

背景情况:

应变工程对于优化生物催化剂电子结构和催化性能至关重要.
精确控制类似酶反应的原子级菌株仍然是一个重大挑战.

研究的目的:

研究原子应变和类似酶的催化活性之间的关系.
在金生物催化剂上设计和评估单个原子,小集群和原子分解集群.

主要方法:

在PdAu生物催化剂上对纳米结构 (Pt1,Ptn,Ptc) 的系统设计.
实验性表征和密度函数理论 (DFT) 计算.
评估过氧化酶 (POD) 类,酶 (CAT) 类和超氧化物异变酶 (SOD) 类活动.

主要成果:

在PdAu (Ptc-PA) 上原子分辨的集群以最佳应变向上移动d波段中心并增加了活性位点.
Ptc-PA表现出异常的POD类活性 (Kcat/Km = 1.50 × 10^9 mM^-1 min^-1),超过了自然胡须过氧化酶 (HRP) 的四个数量级.
观察到可比的CAT类和SOD类活动,以及癌症诊断系统的显著改进和炎症损伤的缓解.

结论:

集群在PdAu上的原子菌株工程是开发高性能生物催化剂的有效策略.
Ptc-PA表现出显著的多酶类活性,有可能用于先进的诊断和治疗应用.
Pd外和Au核心通过储存能量电荷载体而有所贡献,从而提高了整体性能.

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