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细胞因子介导的CAR T治疗在AML中的耐药性

Anand S Bhagwat1,2, Leonel Torres2,3, Olga Shestova2

  • 1Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Nature medicine
|September 27, 2024
PubMed
概括

对急性髓性白血病 (AML) 的自主抗CD123CAR T细胞疗法是可行的,但有效性有限. 一种独特的抵抗机制,涉及骨髓支持细胞因子,阻碍了治疗的成功,这表明需要组合疗法.

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