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Updated: Jun 14, 2025

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Cell Based Assays of SINEUP Non-coding RNAs That Can Specifically Enhance mRNA Translation

Published on: February 1, 2019

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在单细胞RNA-seq中引入合成恒温RNase抑制剂

Joyce Carol Noble1, Antonio Lentini1, Michael Hagemann-Jensen2

  • 1Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

Nature communications
|September 27, 2024
PubMed
概括

一种新的合成RNase抑制剂SEQURNA提高了单细胞RNA测序 (scRNAseq) 库的质量. 这项创新提高了可重复性,并使新的工作流成为可能,这标志着转录学研究的重大进步.

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RNA Interference

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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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