与生物标志物概况和患者预后相关联的COVID-19严重程度
R C S Danielle1,2, D M Débora1, N L P Alessandra2
1Department of Biological Sciences, Federal University of Espírito Santo, Vitória, 29075-910, Brazil.
Scientific reports
|September 27, 2024
概括
这项研究确定了影响COVID-19严重程度和长期COVID (LC) 的关键因素,包括年龄,诸如糖尿病之类的并发症,以及诸如二次体D之类的生物标志物.内皮细胞激活似乎是这些长期影响的重要潜在机制.
科学领域:
- * 传染病 传染病
- * 内部医学 内部医学
- * 遗传学 在遗传学方面
背景情况:
- *长期COVID (LC) 在全球范围内提出了多样化和持久的临床挑战.
- *了解预测COVID-19严重程度和LC的因素对于患者管理至关重要.
- *生物标志物和社会人口统计数据为疾病轨迹提供了洞察力.
研究的目的:
- * 调查社会人口因素,生物标志物和COVID-19严重程度之间的相关性.
- * 探索COVID-19和长期COVID的临床谱和后果.
- * 确定潜在的疾病进展和长期并发症的潜在机制.
主要方法:
- *对226名参与者进行了COVID-19严重程度和长期COVID的评估.
- *评估了社会人口统计数据,病史 (糖尿病,心血管疾病,慢性肺病),MTHFR基因变异rs1801133和凝血标志物 (第八因子,·维勒布兰德因子,二次体D).
- *对参与者进行了6个月的监测,以跟踪生物标志物变化并确定系统性后续.
主要成果:
- *COVID-19的严重程度与年龄,低学历,种族,超重状况,MTHFR rs1801133,心血管疾病,糖尿病,第八因子,·维勒布兰德因子和二次体D有关.
- * 感染后六个月,因子VIII,·维勒布兰德因子和二次体D水平下降,只有二次体D正常化.
- * 关节疼痛和肌痛在患有糖尿病史,慢性肺部疾病和持续高interleukin-6的患者中更为普遍.
- * 慢性肺病,COVID-19的严重程度和高的二次体D水平增加了喘息和心的风险.
- *女性患下肢炎的发病率较高;康复期高的VIII因子与胀风险相关.
- * 定期体育活动显示对抗胀有保护作用.
结论:
- *社会人口因素和特定的生物标志物显著影响COVID-19的严重程度和长期COVID的发展.
- *内皮细胞激活被认为是COVID-19和长期COVID的关键机制.
- *通过这些因素识别高风险个体可以指导有针对性的干预和管理策略.
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