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肝炎A疫苗在血清阴性肝移植儿童中具有免疫性

Palittiya Sintusek¹, Siriporn Khunsri², Preeyaporn Vichaiwattana³

¹Center of Excellence in Thai Pediatric Gastroenterology, Hepatology and Immunology (TPGHAI), Faculty of Medicine, Department of Pediatrics, King Chulalongkorn Memorial Hospital and Thai Red Cross Society, Chulalongkorn University, Bangkok, 10330, Thailand. palittiya.s@chula.ac.th.

Scientific reports

|September 28, 2024

概括

肝移植儿童的甲型肝炎病毒 (HAV) 疫苗接种在移植前的覆盖率较低,但无活化HAV疫苗在移植后是安全和免疫的. 改进的疫苗接种策略对于这个脆弱的人群至关重要.

科学领域:

儿科肝病学儿科肝病学
疫苗学疫苗学疫苗学
免疫学免疫学免疫学

背景情况:

关于A型肝炎病毒 (HAV) 疫苗在儿科肝移植 (LT) 接受者中的疗效的数据有限.
在这个人群中评估血清免疫和疫苗反应是非常关键的,因为他们的免疫力受损.

研究的目的:

为了确定所有LT儿童的HAV血清免疫.
评估非活性化HAV疫苗在血清阴性LT儿童中的免疫性和安全性.

主要方法:

对105名LT儿童的疫苗接种记录的回顾性审查.
对83名血清阴性LT儿童进行前性研究,这些儿童接受了两剂非活化HAV疫苗 (0和6-8个月).
疫苗接种后不良事件和血清阳性率的监测.

主要成果:

只有81%的LT儿童有可用的疫苗接种记录,移植前免疫率低 (7.1%一剂,16.5%两剂).
接种疫苗后的血清阳性在第一剂后达到51.5%,第二剂后达到92.9% (p < 0.001).
没有报告严重的不良事件;年龄和移植后的时间是不反应的风险因素.

结论:

在LT儿童中,HAV疫苗接种覆盖率不足,增加了对感染的易感性.
非活性化HAV疫苗具有高度免疫性,对血清阴性LT儿童是安全的.
对这一高风险群体来说,需要加强肝移植前后的疫苗接种策略.

关键词:

孩子孩子孩子孩子甲型肝炎病毒的病毒.豁免权是一种豁免权.肝脏移植是什么?肝移植是什么?疫苗的免疫原性疫苗的免疫原性

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