偏头痛和糖尿病之间的流行病学联系:系统性审查和元分析
Woo-Seok Ha1, Vinh Khang Nguyen2, Min Kyung Chu3,4
1Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of Korea.
The journal of headache and pain
|September 28, 2024
概括
糖尿病 (DM) 与偏头痛的发生率较低有关,特别是1型糖尿病. 然而,偏头痛,特别是没有光环的偏头痛,与DM的发生率更高有关,尽管证据质量较低.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 流行病学 流行病学
背景情况:
- 糖尿病和偏头痛之间的关系是复杂的,需要进一步阐明.
- 现有研究对这些条件之间的双向关联提出了相互矛盾的发现.
研究的目的:
- 系统地审查和分析有关糖尿病和偏头痛之间关联的现有文献.
- 确定DM与偏头痛发生和风险之间的关系的性质和程度.
主要方法:
- 在PubMed,Web of Science和Scopus数据库中进行了全面的搜索.
- 包括横截面和队列研究,至少包括年龄和性别调整.
- 提取数据以计算几率比率 (ORs) 和危险比率 (HRs);使用纽卡斯尔-太华尺度评估偏差风险.
主要成果:
- 八项横截面研究的元分析发现DM和偏头痛之间没有总体显著的关联.
- 亚组分析表明,1型糖尿病降低了偏头痛的几率 (OR 0.48),而没有光环的偏头痛增加了DM的几率 (OR 1.19).
- 四项队列研究表明,DM降低了偏头痛风险 (HR 0.83),而偏头痛史增加了DM风险 (HR 1.09).
结论:
- 糖尿病,特别是1型糖尿病,与偏头痛发生有负面关联.
- 偏头痛,尤其是没有光环的偏头痛,与DM发生有积极的关联.
- 总体证据质量低至非常低,需要进一步进行高质量的研究.
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