饮食总抗氧化能力和肺癌的几率:一项大型病例对照研究
Fatemeh Toorang1,2, Monireh Sadat Seyyedsalehi1,2, Bahareh Sasanfar1,3,4
1Cancer Research Center, Cancer Institute, Tehran University of Medical Science, Tehran, Islamic Republic of Iran.
BMC cancer
|September 28, 2024
概括
富含抗氧化剂的饮食,以饮食总抗氧化剂容量 (dTAC) 衡量,与患肺癌 (LC) 的几率较低有关. 在各种子组中观察到这种保护作用,强调了富含抗氧化剂的食物对每个人的重要性.
科学领域:
- 营养科学 营养科学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 肺癌 (LC) 仍然是全球重要的健康问题.
- 饮食因素在预防癌症方面发挥着至关重要的作用.
- 了解饮食总抗氧化能力 (dTAC) 对LC风险的影响至关重要.
研究的目的:
- 在伊朗人口中调查饮食总抗氧化能力 (dTAC) 与肺癌 (LC) 风险之间的联系.
- 评估dTAC和LC几率之间的剂量反应关系.
- 探索人口统计和生活方式因素对这种协会的潜在修改影响.
主要方法:
- 一项病例对照研究,涉及病学诊断的LC患者和来自伊朗的健康对照.
- 使用经过验证的食物频率问卷 (FFQ) 评估的饮食习惯.
- 使用铁降解抗氧化功率 (FRAP) 和总激素捕捉抗氧化参数 (TRAP) 评分测量的dTAC.
- 使用无条件逻辑回归来估计几率比率 (OR) 和95%置信区间 (CI),调整为混因素.
主要成果:
- 较高的FRAP和TRAP得分与较低的LC几率显著相关 (例如,OR=0.53对于最高与最低的FRAP三位数).
- 对于FRAP和TRAP得分 (p <0.01) 均观察到显著的逆剂量反应趋势.
- 在所有LC组织类型和子组 (性别,年龄,吸烟,片使用) 中,dTAC和LC风险之间的反向关联是一致的.
结论:
- 更高的饮食总抗氧化能力 (dTAC) 与肺癌的几率降低密切相关.
- 这些发现强调了食用富含抗氧化剂的饮食对于预防所有个体的肺癌的重要性,无论风险因素如何.
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