在患有多囊性卵巢综合征的女性中,高雄性和人类参数
Asieh Mansour1, Maryam Noori2,3, Monir Sadat Hakemi4
1Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
BMC endocrine disorders
|September 28, 2024
概括
腰与身高的比率 (WHtR) 是肥胖与多囊性卵巢综合征 (PCOS) 妇女荷尔蒙乱相关的最佳指标. 这一发现表明,WHtR可以帮助识别PCOS患者的过高雄性质.
科学领域:
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 多囊卵巢综合征 (PCOS) 的特点是脂肪组织增加,导致荷尔蒙失衡.
- 肥胖和荷尔蒙乱是PCOS的关键特征,影响女性的健康.
研究的目的:
- 确定最有效的肥胖指标来评估PCOS妇女的荷尔蒙乱.
- 为了比较各种人类指数与PCOS中的荷尔蒙失衡的关联.
主要方法:
- 根据鹿特丹标准诊断的129名PCOS妇女的横截面分析.
- 评估人类测量指标,包括BMI,腰围和腰与身高比 (WHtR).
- 线性回归和ROC曲线分析,以评估肥胖指标与荷尔蒙参数 (如自由原体指数 (FAI) 和SHBG) 之间的关联.
主要成果:
- 多种人体指数,包括BMI,腰围,WHtR和脂肪质量,与激素失衡 (FAI和SHBG) 有关.
- WHtR在识别高雄性质方面显示了0.676的最高曲线下面面积 (AUC) (P=0.001).
- 最佳WHtR切线点显示了87.30%的灵敏度和39.70%的特异性来检测过高雄性.
结论:
- 腰与身高的比率 (WHtR) 优于其他人体测量指标,因为它与PCOS中的过高雄性质有关.
- WHtR 作为一种有价值的工具,用于识别患有 PCOS 的女性的荷尔蒙障碍,特别是高雄激素主义.
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