在成年人中,循环血清Klotho和代谢成分之间的性别特异关联
Zhenzhen Wang1, Hang Zhang2, Guixia Zheng3
1Cancer Center, Department of Ultrasound Medicine, Affiliated People's Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, 158 Shangtang Road, Hangzhou, 310014, China.
血清Klotho水平显示性别差异,并与代谢综合征 (MetS) 组成部分联系在一起. 甘油三胺在女性中与克洛托强烈相关,而高密度脂蛋白胆固醇 (HDL) 在男性中是关键.
科学领域:
- 内分泌学和新陈代谢学
- 老年学是一门学科.
- 心血管健康 心血管健康
背景情况:
- 克洛托对于衰老和心血管健康至关重要.
- 代谢综合征 (MetS) 的组成部分增加了心血管疾病和糖尿病的风险.
- 了解特定于性别的Klotho差异和MetS联系很重要.
研究的目的:
- 为了研究血清Klotho水平的性别特异性差异.
- 为了检查Klotho和代谢综合征的组成部分之间的关联.
- 确定与Klotho和MetS相关的性别特异性因素.
主要方法:
- 对2015-2016年国家健康和营养检查调查数据库的分析.
- 用2005年AHA/NHLBI标准定义的代谢综合征.
- 检查血清Klotho的性别特异性差异及其与MetS组件的关联.
主要成果:
- 低Klotho与年龄较大,男性性别,吸烟,高甘油三,脏问题,炎症和低性激素有关.
- 在女性中,Klotho-MetS相关性更强 (腰围,甘油三).
- 在与Klotho相关的因素中发现的性别差异,独立于年龄和功能.
结论:
- 克洛托水平表现出性别差异,独立于年龄,功能和性激素.
- 甘油三是一种主要的MetS成分,与Klotho独立相关,特别是在女性中.
- 高密度脂蛋白胆固醇 (HDL) 是一个男性特异性的MetS成分,与Klotho独立相关.
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