在乌干达,与艾滋病毒感染者生活的老年人中,功能障碍的患病率更高
Amutuhaire Judith Ssemasaazi1,2, Robert Kalyesubula3, Yukari C Manabe4,5
1Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda. amutuhairejudith@gmail.com.
BMC nephrology
|September 28, 2024
概括
与没有艾滋病毒的老年人相比,感染艾滋病毒的老年人面临更高的功能障碍风险. 在这种人群中,早期监测脏健康对于预防疾病进展至关重要.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 艾滋病毒感染者 (PLWH) 容易受到艾滋病毒,抗逆转录病毒疗法 (ART),糖尿病和高血压的功能障碍的影响.
- 慢性病 (CKD) 的患病率随着年龄的增长而增加,这可能会加剧老年PLWH的风险.
- 关于老年PLWH与撒哈拉以南非洲普通老年人群中功能障碍的数据有限.
研究的目的:
- 为了比较患有艾滋病毒的老年人与没有艾滋病毒的老年人中功能障碍的患病率,在乌干达坎帕拉.
- 在这个人口群体中确定与功能障碍相关的因素.
主要方法:
- 在乌干达坎帕拉进行了一项横截面研究,将老年人 (≥60岁) 与艾滋病毒感染者和没有艾滋病毒感染者相匹配,按位置分为1:1.
- 收集的数据包括社会人口统计,并发症和艾滋病毒特定的临床细节.
- 功能障碍被定义为估计的膜过率 (eGFR) < 60mL/min/1.73m2 有或没有蛋白尿.
主要成果:
- 该研究包括278名参与者 (平均年龄66岁;50%的PLWH).
- 与没有艾滋病毒 (12.9%) (p<0.01) 相比,PLWH患者中功能障碍的发生率显著高 (33.1%) (p<0.01).
- 蛋白尿也更常见于PLWH (43.9%) 比艾滋病毒阴性组 (19.4%) (p<0.01).
- 携带艾滋病毒 (OR=3.89),年龄较大 (OR=1.13),女性性别 (OR=1.95) 和高血压 (OR=2.19) 与功能障碍有关.
结论:
- 艾滋病毒感染是老年人功能障碍的重要危险因素.
- 建议在老年PLWH患者中定期监测功能和蛋白尿,以进行早期检测和管理.
- 这些干预措施可以帮助缓解病在这个脆弱人群中的进展.
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