INTOXICATE研究:前性观察研究的方法和初步结果
Samanta M Zwaag1, Irma S van den Hengel-Koot1, Stuart Baker2
1Dutch Poisons Information Center (DPIC), University Medical Center Utrecht, Utrecht, The Netherlands.
Critical care (London, England)
|September 28, 2024
概括
大多数因急性中毒而入院的成人重症监护病房 (ICU) 患者都会经历一场令人难以置信的入院,需要通风或血管压缩器等干预措施. 然而,许多人幸存下来,有些人不需要ICU特定的治疗.
科学领域:
- 毒理学 毒理学 毒理学
- 关键护理医学 关键护理医学
- 临床研究 临床研究
背景情况:
- 没有现有的基于实践的多中心数据库,用于重症监护室 (ICU) 中的中毒患者.
- 为了弥补这个差距,INTOXICATE研究被建立起来,ESICM和EAPCCT都赞同.
- 目标:确定急性中毒成年ICU患者的事件性入院率.
研究的目的:
- 建立第一个基于实践的,针对急性中毒成年ICU患者的多中心数据库.
- 为了确定在ICU住院的前24小时内"偶然入院"的比例.
- 收集有关人口统计,暴露,临床特征和结果的综合数据.
主要方法:
- 多中心,有道德认可和数据共享协议的前性观察研究.
- 通过电子病例报告表格收集的数据,包括人口统计,暴露,临床数据,治疗和死亡率.
- 主要结局:通过特定的ICU干预或24小时内在医院死亡来定义的"可能入院".
主要成果:
- 78个ICU参与,在2020年11月至2023年6月期间招收了2,273名成年患者.
- 患者的中位年龄为41岁,其中72%的人接触过麻醉药物.
- 68%的患者有事件性ICU入院;医院死亡率为4.5%.
结论:
- 大多数急性中毒的ICU患者经历了事件性入院,需要进行重症监护干预.
- 大约三分之一的患者不需要ICU特定的干预措施.
- 该研究产生了关于严重急性中毒模式和ICU环境中的结果的高质量数据.
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