提尼达口水用于治疗平坦口:一项观察性试点研究
Ruru Shao1,2, Zhenyuan Wang3, Chenglong Yang3
1Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
BMC oral health
|September 28, 2024
概括
提尼达口腔冲洗显示治疗口腔平坦 (OLP) 的承诺,减少症状和耐受性良好. 需要进一步的随机对照试验来确认其作为OLP局部治疗的有效性.
科学领域:
- 口腔医学是指口腔医学.
- 皮肤病学 皮肤病学
- 微生物学 微生物学
背景情况:
- 口腔平坦 (OLP) 具有有限的治疗选择.
- 研究OLP的新疗法至关重要.
研究的目的:
- 为了评估tinidazole口腔冲洗在OLP患者的初步治疗疗效.
- 评估tinidazole对OLP病变严重程度和口腔微生物群的影响.
主要方法:
- 一项前性的开放标签试点研究,涉及27名OLP患者.
- 评估的网膜/红斑/ (REU) 和视觉模拟尺度 (VAS) 分数.
- 使用RT-PCR量化了Fusobacterium核的丰富性.
主要成果:
- 丁醇口腔冲洗显著降低了网状和侵蚀性OLP的VAS得分.
- 仅在侵蚀性OLP患者中,REU得分显著改善.
- 在OLP患者中减少了Fusobacterium nucleatum丰富度;在侵蚀性OLP中,triamcinolone显示出更好的VAS改善.
结论:
- 丁醇口腔冲洗显示出降低OLP严重性的潜力,并且耐受性良好.
- 它可以作为OLP的可行的局部治疗选择.
- 推随机对照研究进行验证.
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