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在冷的肩膀中对铁亡的生物信息学分析

Hongcui Zhang¹, Jiahua Zhou², Zhihua Liu³

¹Department of Rehabilitation Medicine, Wendeng Orthopedic and Traumatic Hospital, Weihai City, Shandong Province, China.

BMC medical genomics

|September 28, 2024

概括

这项研究将细胞死亡过程铁亡与冷肩病联系起来. 像IL-6,HMOX1和TLR4这样的关键基因被确定为冷肩治疗的潜在治疗标.

科学领域:

生物化学生物化学
分子生物学分子生物学
免疫学免疫学免疫学

背景情况:

结的肩膀显著影响日常生活和工作.
铁亡,一种新的编程细胞死亡,与各种疾病有关.
结的肩膀和ferroptosis之间的关系仍然没有被探索.

研究的目的:

在冷的肩膀中识别铁亡的分子标记物.
探索基于ferroptosis的结肩膀的潜在治疗策略.
为了研究铁灭菌在冷肩部病变发生中的作用.

主要方法:

分析了基因表达综合 (GEO) 数据集 GSE238053 并与铁灭基因交叉.
利用WebGestalt和Metascape进行差异表达基因 (DEGs) 路径和功能丰富分析.
使用STRING和Cytoscape进行基因相互作用网络分析,并在使用西布洛特和qRT-PCR的老鼠模型中验证了关键基因 (IL-6,HMOX1,TLR4).

主要成果:

在冷肩和铁死之间确定了34个DEG,主要与HIF-1信号和炎症反应有关.
通过蛋白质-蛋白质相互作用网络分析选关键基因IL-6,HMOX1和TLR4.
观察到TLR4和HMOX1的蛋白质水平升高,IL-6蛋白质降低,以及在冷肩的老鼠模型中,上调的IL-6mRNA与下调的TLR4和HMOX1mRNA.

结论:

铁亡可能会通过已识别的信号通路和基因影响结肩部病理.
IL-6,HMOX1和TLR4代表了冷肩治疗的潜在新型治疗标.

关键词:

生物信息学是一种生物信息学.铁性化 (ferroptosis) 是一种冰的肩膀在冰的肩膀

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