相关实验视频

Updated: Jun 11, 2025

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

脂质蛋白 (a) 和风险加权的阿波脂质蛋白 (B):一种新型的异构体风险指标

Michaela B Rehman¹, Benoit V Tudrej²

¹Cardiology Department, Ramsay Santé, Médipôle Lyon-Villeurbanne, 158 rue Léon Blum, Villeurbanne, 69100, France. michaela.rehman@ramsaysante.fr.

Lipids in health and disease

|September 28, 2024

概括

在患有高脂蛋白 (Lp) 的患者中,阿波蛋白B (apoB) 可能低估了动脉样硬化心血管疾病 (ASCVD) 的风险. 风险加权的apoB提供了一种新的指标,可以准确评估整体脂质驱动的风险.

科学领域:

心血管医学心血管医学
脂质代谢脂质代谢是什么
动脉样硬化研究动脉样硬化研究

背景情况:

含有Apolipoprotein B (apoB) 的脂蛋白是动脉样硬化心血管疾病 (ASCVD) 发病的核心.
量化apoB直接估计了无氧化物颗粒的数量,使其成为ASCVD风险评估的关键指标.
升高的脂蛋白 (Lp) 构成一个重大挑战,因为apoB可能低估了由于Lp的较高血性而导致的风险.

研究的目的:

解决apoB对Lp升高个体中ASCVD风险的低估问题.
开发一种实用的临床工具,用于评估全面的脂质驱动性动脉风险.
阐明Lp(a) 和apoB对冠心病 (CHD) 风险的不同贡献.

主要方法:

引入了一种新型指标:风险加权的阿波利波蛋白B (apoB + Lp(a) x 6).
计算apoB捕获的风险比例 (apoB / 风险加权的apoB).
计算由Lp (a) (Lp (a) x 7 / 风险加权apoB) 承担的风险比例.

主要成果:

新的风险加权apoB指标与流行病学和孟德尔随机化研究中确定的风险估计有很强的一致性.
这一新指标有效地解释了Lp(a) 颗粒的异构性增加.
与单独的apoB相比,它更准确地表示了整体动脉质风险.

结论:

标准的apoB测量显著低估了高Lp(a) 水平的患者的ASCVD风险.
在高Lp的存在下,apoB和事件CHD之间的关联可能会减少或消失.
风险加权的apoB提供了一个解决方案来克服和解释这些差异,提供更准确的风险评估.

关键词:

乙类阿波利波蛋白 (B) 是一种阿波利波蛋白.动脉样硬化心血管疾病.冠心病是一种冠心病.脂蛋白 (a) 是一种蛋白质这是一个新的指标.风险评估风险评估风险评估

更多相关视频

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

Quantification of Atherosclerosis in Mice

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

相关概念视频

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...

Coronary Artery Disease I: Introduction

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...

Cholesterol: Significance and Regulation

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...

Coronary Artery Disease IV: Medical Management

Coronary Artery Disease IV: Medical Management

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...

Atherosclerosis III: Management

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...