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作为预测COVID-19住院患者死亡的潜在生物标志物,Pentraxin-3 (PTX-3) 是一种潜在的生物标志物

Milena Xavier Silva Barbosa¹, Anderson da Costa Armstrong², Carlos Dornels Freire de Souza²

¹Postgraduate Program in Biosciences, Universidade Federal do Vale do São Francisco, Av. José de Sá Maniçoba. sn, Petrolina, Pernambuco, Brazil.

Virology journal

|September 28, 2024

概括

潘特拉辛3 (PTX3) 是预测住院COVID-19患者死亡率的有希望的生物标志物. 入院时较高的PTX3水平表明死亡风险显著增加,超过其他常见标志物.

科学领域:

生物化学生物化学
免疫学免疫学免疫学
临床医学临床医学

背景情况:

潘特拉辛3 (PTX3) 是一种急性阶段蛋白质,参与病原体防御和炎症.
升高的PTX3水平与炎症状况和传染病有关,包括COVID-19.
目前正在研究PTX3作为一种潜在的诊断和预后生物标志物.

研究的目的:

评估Pentraxin 3 (PTX3) 作为预测住院COVID-19患者死亡率的血生物标志物.
确定入院时PTX3水平与患者生存结果之间的关联.
将PTX3的预测性能与已确定的临床标志物进行比较.

主要方法:

分析了2020年7月至2021年8月期间入院的312名COVID-19患者的队列.
血PTX3水平使用ELISA在入院后24小时内得到量化.
统计分析包括最大选择等级统计,ROC曲线,Kaplan-Meier生存分析和Cox回归.

主要成果:

与幸存者 (n=233) 相比,死亡的患者 (n=79) 的入院PTX3水平显著更高 (中位数为52.84与10.79 ng/mL;p < 0.001).
与C-反应蛋白 (AUC=0.72) 和D-二次体 (AUC=0.77) 相比,PTX3的预测性能更好 (AUC=0.834).
27.3 ng/mL的PTX3截止值确定了存活率较低的患者 (p=0.014),PTX3>27.3 ng/mL是死亡的独立预测因子 (HR=1.79;p=0.027).

结论:

原素3 (PTX3) 显示出作为COVID-19患者死亡率预后生物标志物的显著潜力.
住院时PTX3水平升高与死亡风险增加有关.
PTX3为住院COVID-19患者的风险分层和临床管理提供了有价值的工具.

关键词:

生物标志物生物标志物在 COVID-19 疫情中,这是天生的免疫力.潘特拉克辛 (Pentraxin) 是一种药物这就是SARS-CoV-2病毒.

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