Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Deep learning-based automatic identification model of main pancreatic duct in intraoperative ultrasonography.

Surgical endoscopy·2026
Same author

The surgical outcomes of modified Chen's U-suture technique compared with duct-to-mucosa anastomosis in laparoscopic pancreaticoduodenectomy: a multi-center cohort study.

Surgical endoscopy·2026
Same author

Abnormal protein glycosylation in epileptogenesis: evidence from experimental models and clinical insights.

Reviews in the neurosciences·2026
Same author

Harnessing Corrosion in A P(VDF-TrFE)/Mg Composite for Dynamic Passivation and Osteoimmunomodulation.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Simulation Study of Enhancement-Mode <i>β</i>-Ga<sub>2</sub>O<sub>3</sub> MOSFETs on a Novel P-Ga<sub>2</sub>O<sub>3</sub>/AlN/SiC Substrate.

Micromachines·2026
Same author

Machine learning-driven high-throughput screening of electrocatalysts and electrolytes for electrochemical surfaces and interfaces.

Chemical communications (Cambridge, England)·2026

相关实验视频

Updated: Jun 11, 2025

Strategies for Assessing Autistic-Like Behaviors in Mice
07:38

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

894

断奶时的自缺陷会损害补充依赖的突触修剪,并诱导行为缺陷.

Xi Su1,2,3,4,5, Guanyu Wang6,7,8, Senqi Liu6,7,8

  • 1Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, 388 Middle Jianshe Road, Xinxiang, 453002, China. suxi198919@163.com.

Journal of neuroinflammation
|September 28, 2024
PubMed
概括
此摘要是机器生成的。

缺陷的自与精神分裂症 (SCZ) 有关. 在老鼠模型中,在生命早期激活自可以逆转SCZ相关的行为和突触缺陷.

关键词:
自自是一种自的过程.补充 补充 补充 补充孕产妇的免疫激活精神分裂症是一种精神分裂症.突触剪裁是指突触剪裁.

更多相关视频

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
07:43

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

11.2K
A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes
06:43

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes

Published on: February 5, 2018

12.1K

相关实验视频

Last Updated: Jun 11, 2025

Strategies for Assessing Autistic-Like Behaviors in Mice
07:38

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

894
Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
07:43

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

11.2K
A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes
06:43

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes

Published on: February 5, 2018

12.1K

科学领域:

  • 神经科学是一个神经科学.
  • 遗传学 遗传学 是一个
  • 细胞生物学 细胞生物学

背景情况:

  • 自对于突触可塑性和树突性脊柱结构至关重要.
  • 自在精神分裂症 (SCZ) 中的特定作用及其对突触功能的影响尚不清楚.

研究的目的:

  • 研究与自相关的基因与SCZ之间的关联.
  • 在SCZ的母体免疫激活 (MIA) 模型中探索自会影响突触功能和行为的机制.

主要方法:

  • 在与SCZ相关的自基因中确定单核酸多态 (SNPs).
  • 在公开的基因表达数据上进行基因组丰富分析 (GSEA).
  • 使用母体免疫激活 (MIA) 鼠标模型,在断奶期间给予拉巴胺素或3-甲基亚丁胺 (3-MA).

主要成果:

  • 在19个与SCZ相关的自基因中发现了995个SNP,并通过GSEA证实了SCZ患者的缺陷自.
  • 在MIA大鼠模型中,自在断奶期间被降低;早期激活拉巴胺素恢复了异常行为和电生理学.
  • 使用3-MA抑制自导致异常行为,电生理学缺陷,脊柱密度增加,并通过破坏补体信号来损害微质介导的突触修剪.

结论:

  • 缺陷的自与SCZ显著相关.
  • 自在调节由MIA引起的突触和行为缺陷方面发挥着关键作用,特别是通过微质介导的突触修剪和补充通路调节.