心血管健康对五个表观遗传时钟的因果影响
Hsien-Liang Sung1, Wan-Yu Lin2,3
1Institute of Health Data Analytics and Statistics, College of Public Health, National Taiwan University, Room 501, No. 17, Xu-Zhou Road, Taipei, 100, Taiwan.
Clinical epigenetics
|September 28, 2024
概括
保持理想的心血管健康 (CVH) 会因果性地减少表观遗传衰老加速. 这项研究表明,改善CVH标志物可以导致生物衰老的减缓和更好的健康结果.
科学领域:
- 遗传学和表观遗传学
- 心血管健康 心血管健康
- 生物老龄化 生物老龄化
背景情况:
- 之前的研究表明,理想的心血管健康 (CVH) 与较慢的表观遗传衰老加速 (EAA) 之间存在关联.
- 之前没有确定CVH和EAA之间的因果关系.
研究的目的:
- 研究理想心血管健康 (CVH) 和表观遗传衰老加速 (EAA) 之间的因果关系.
- 探索单个CVH组件对各种表观遗传衰老措施的影响.
主要方法:
- 用台湾生物库数据进行全基因组关联研究 (GWAS) 和门德尔随机化 (MR) 分析.
- 进行了单样和双样MR分析,以评估CVH得分及其组成部分对EAA指标 (如GrimAge和Horvath的内在表观遗传年龄) 的因果关系.
主要成果:
- 总体CVH得分对GrimAge加速 (GrimEAA) 和基于DNA甲基化的等离子素激活剂抑制剂-1 (DNAmPAI-1) 的显著因果作用被观察到.
- 理想的总胆固醇和体重指数 (BMI) 分数显示与DNAmPAI-1和GrimEAA的因果关系.
- 在欧洲人群中,CVH得分,BMI,从不吸烟,步行和干果摄入量都对GrimEAA产生了因果关系.
结论:
- 这项研究证实了维持理想的心血管健康和缓慢表观遗传衰老之间的因果关系.
- 优化心血管健康对于旨在减缓生物衰老的个人来说是一个可行的策略.
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