在阿尔茨海默病中探索镜像自我错误识别的神经机制
Zhen Sun1,2,3, Gang Chen1,4, Jinghuan Gan5
1Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China.
International journal of geriatric psychiatry
|September 28, 2024
概括
患有镜子自我错误识别 (MSM) 的阿尔茨海默病患者在特定的大脑区域显示出血脑屏障 (BBB) 透性增加. 这种BBB在左侧膜和白色球体中的分解可能是阿尔茨海默病中MSM的风险因素.
科学领域:
- 神经成像是一种神经成像.
- 神经退行发生神经退行.
- 阿尔茨海默氏症疾病研究研究
背景情况:
- 阿尔茨海默病 (AD) 是一种神经退行性疾病.
- 镜子自我误认综合征 (MSM) 是AD的一种认知障碍.
- 在AD中MSM的神经机制尚未完全理解.
研究的目的:
- 为了研究在AD中MSM的神经机制.
- 探索血脑屏障 (BBB) 透性在MSM中的作用.
- 使用动态对比增强磁共振成像 (DCE-MRI) 进行定量BBB评估.
主要方法:
- 招募了48名AD患者 (13名MSM,35名非MSM).
- 使用DCE-MRI和计算的传递率 (Ktrans) 的量化BBB透度.
- 分析了半球,大脑区域和MSM严重程度之间的Ktrans差异,使用统计测试和后勤回归.
主要成果:
- 在MSM群体中观察到左丘脑,门,白色球体,冠状辐射和右尾状体的Ktrans值升高.
- 增加Ktrans在左侧膜和白色球体被确定为MSM的潜在风险因素.
- 较高的甲状腺Ktrans与中度至重度的MSM相关,表明与疾病严重程度的联系.
结论:
- 在阿尔茨海默氏症中,MSM与左门和白色球体的BBB分解有关.
- 这些大脑区域可能在镜子自我识别中发挥关键作用.
- lamus中BBB透率的增加可能表明MSM患者的AD的严重程度.
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