德罗纳比诺尔不是儿童息治疗中的游戏改变者:一项回顾性研究的结果
Holger Hauch1,2, Annika Lisakowski2,3, Julia Wager1,2,3
1Pediatric Palliative Care Centre, Children's and Adolescents' Hospital Datteln, 45711 Datteln, Germany.
Children (Basel, Switzerland)
|September 28, 2024
概括
德罗纳醇 (DRB) 对于儿童住院患者的性和不安等症状的疗效有限. 观察到包括呼吸抑制在内的严重副作用,需要谨慎使用.
科学领域:
- 儿科息护理是儿童的息护理.
- 神经药理学神经药理学
- 大麻素治疗疗法.
背景情况:
- 患有生命限制疾病 (LLCs) 的患者会出现不安,,疼痛和等症状.
- 一种大麻素dronabinol (DRB) 可能会提供缓解,但LLC的儿科住院患者的数据很少.
- 这项研究旨在评估DRB在这个人群中的有效性和安全性.
研究的目的:
- 评估Dronabinol (DRB) 在儿童住院患者患有生命限制疾病 (LLCs) 的症状管理方面的有效性.
- 评估德罗纳比诺 (DRB) 在这个脆弱的患者群体中的安全性.
- 为了比较DRB在住院期间启动的疗效与之前使用的疗效.
主要方法:
- 从2011年到2021年的住院患者数据的回顾性分析.
- 包括63名患有LLC的儿科患者接受DRB治疗,主要是那些患有神经疾病的患者.
- 在研究期间开始使用DRB的患者与在入院时已经使用DRB的患者的比较.
主要成果:
- 报告了对性 (47.6%) 和不安 (27%) 的主观改善,但客观测量显示或不安没有减少.
- 新开始治疗的患者 (0.21 mg/kg/BW/day) 和已经接受治疗的患者 (0.48 mg/kg/BW/day) 的有效DRB剂量有所不同.
- 严重的副作用,包括呼吸抑制,发生在三名患者身上,也报告了疲劳和行为问题.
结论:
- 在患有LLC的儿科住院患者中,dronabinol (DRB) 的主观益处没有得到客观数据的一致支持.
- 严重不良事件的可能性需要仔细监测和对DRB使用的明确指示.
- 对于患有生命限制疾病的儿科患者,DRB的启动应在受控,监测的环境中进行.
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