怀孕期间胎儿症状与新生儿临床并发症与毒素菌之间的关联
Nándor Tűzkő1, Virág Bartek2, Atene Simonyi2
1Department of Obstetrics and Gynecology, St. Margaret's Hospital, 1032 Budapest, Hungary.
Children (Basel, Switzerland)
|September 28, 2024
概括
毒素菌是一种常见的寄生虫感染,可在孕妇中引起严重问题. 通过羊水PCR测试及多学科随访进行早期检测对于管理孕产妇和新生儿并发症至关重要.
科学领域:
- 医学寄生虫学 医学寄生虫学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 传染性疾病 传染性疾病
背景情况:
- 毒素菌,由*Toxoplasma gondii*引起,是全世界普遍存在的寄生虫感染.
- 虽然在免疫能力强的个体中无症状,但在怀孕期间存在重大风险,可能导致严重的胎儿发育异常,特别是影响中枢神经系统和胃肠道系统.
研究的目的:
- 评估胚胎液PCR对*Toxoplasma gondii*在最近发生的孕产妇感染中的诊断效用.
- 评估怀孕后果和与毒素菌相关的新生儿并发症.
主要方法:
- 通过血清学确认的孕产妇感染的前性分析 (1996-2020).
- 在最近发生的母亲感染的情况下,对*Toxoplasma gondii*进行PCR检测.
- 全面的新生儿检查 (神经学,眼科,微生物学) 和随访.
主要成果:
- 进行了238次羊水PCR测试;其中8次阳性检测出了*Toxoplasma gondii*.
- 133例怀孕显示超声波异常,主要影响神经和胃肠系统.
- 在139名被跟踪的新生儿中,22名新生儿出现了可能与毒素菌相关的并发症,尽管这些病例的胎液PCR结果是负的.
结论:
- 胚胎液PCR测试,除了血清学方法,有助于诊断胎儿毒素菌并告知怀孕管理决策.
- 疑似病例中的超声波异常通常涉及胎儿的神经系统和胃肠道系统.
- 由毒素症复杂化的怀孕的管理需要多学科的团队方法,以获得最佳的孕产妇和新生儿护理.
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