儿科慢性病中的乳二及其与心血管风险的关系
Chun-Yi Ho1,2, Pei-Chen Lu1, Wei-Ling Chen1
1Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.
Children (Basel, Switzerland)
|September 28, 2024
概括
乳酸 (LF) 可能有助于在患有慢性病 (CKD) 的儿童中早期发现心血管疾病 (CVD). 较低的LF水平与动脉硬度增加和血压异常相关,表明LF.
科学领域:
- 儿科脏病学 儿科脏病学
- 心血管研究研究心血管研究
- 生物标志物发现发现
背景情况:
- 患有慢性病 (CKD) 的儿童面临心血管疾病 (CVD) 的风险增加.
- 儿科CKD中的亚临床心血管疾病可以使用心动脉内心介质厚度 (cIMT),门诊血压监测 (ABPM) 和动脉硬指数来确定.
- 乳酪蛋白 (LF) 是母乳中的糖蛋白,目前正在研究其潜在的作用以及作为各种疾病中的生物标志物.
研究的目的:
- 研究患有CKD的儿童中乳酸铁素 (LF) 水平和心血管 (CV) 风险标志物之间的关系.
- 探索LF作为儿科CKD中亚临床心血管疾病的生物标志物的潜力.
主要方法:
- 该研究包括了102名被诊断患有G1-G4.4阶段CKD的儿童.
- 与CKD严重程度,原因,超重/肥胖,cIMT,动脉硬以及ABPM概况相关的评估LF度.
主要成果:
- 流度与CKD的严重程度或原因没有关联,但与超重/肥胖有积极的相关性.
- 较低的LF水平与增加的cIMT和动脉硬性有关.
- 六成患有CKD的儿童表现出ABPM异常,低LF与夜间高血压和夜间不浸泡有关.
结论:
- 乳酸 (LF) 显示出作为检测儿科慢性病 (CKD) 中亚临床心血管疾病 (CVD) 的生物标志物的潜力.
- 使用LF的早期检测可以促进及时干预,改善患有CKD的儿童的长期心血管结果.
- 需要进一步的研究,以阐明在儿科慢性病中连接LF和心血管健康的潜在机制.
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