链接GERD和炸弹:一种新的治疗策略来调节炎症,氧化应激和临床生物化学参数
Alessio Ardizzone1, Sarah Adriana Scuderi1, Lelio Crupi1
1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy.
Antioxidants (Basel, Switzerland)
|September 28, 2024
概括
在GERD模型中,Bombesin治疗显著降低了腹痛和炎症标志物. 这种还恢复了胃内稳定,显示出治疗胃食道逆流病的前景.
科学领域:
- 胃肠病学 胃肠病学
- 分子生物学分子生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 胃食道逆流性疾病 (GERD) 是一种广泛的前肠疾病.
- 炎症媒介,氧化应激 (ROS/RNS) 和改变的细胞因子有助于GERD的发病.
- 在GERD中,bombesin和胃素释放 (GRP) 的作用尚未得到充分研究.
研究的目的:
- 为了研究bombesin在GERD中的治疗潜力.
- 在GERD模型中评估bombesin对炎症和氧化/化应激标志物的影响.
- 为了评估bombesin对胃pH和恒温的影响.
主要方法:
- 在C57BL/6小鼠中,通过交替过度养和禁食56天诱导了GERD.
- 小鼠每天接受内注射的bombesin (0.1,0.5,1毫克/公斤) 或omeprazole 7天.
- 胃疼痛,炎症标志物,氧化/化应激标志物和胃pH值在治疗后被评估.
主要成果:
- 庞贝塞因的使用显著减少了腹部疼痛.
- 梅素有效地减少了炎症和氧化/化应激标志物,与梅相似.
- 梅素治疗调节了胃的pH值,表明胃平衡得到恢复.
结论:
- 庞贝西因显示出作为GERD的替代治疗剂的潜力.
- 庞贝和相关的升级可能为GERD患者提供一种新的治疗策略.
- 庞贝西因减少疼痛和炎症的能力突出了其在GERD中的治疗价值.
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