预测巴雷特食道的回归 - - 所有国王的人都能把它放在一起吗?
Martin Tobi1, Nabiha Khoury1,2, Omar Al-Subee1
1Departments of Medicine, Research and Development, John D. Dingell VAMC, 3636 John R. St., Detroit, MI 48201, USA.
Biomolecules
|September 28, 2024
概括
巴雷特食道 (BE) 在一些患者中可以自发回归 (SR). 年轻的年龄,较低的血小板和特定的免疫标记与SR有关,这表明对食道瘤的潜在干预措施.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 巴雷特食道 (Barrett's esophagus,BE) 是下食道的前新生病变,增加癌症风险,特别是在患有GERD和肥胖的白人男性中.
- 目前的BE管理包括内镜监测和切除,但成本效益和根除成功仍在争论中,需要新的方法.
研究的目的:
- 调查BE的自发回归 (SR) 并确定相关的临床和免疫因素.
- 探索潜在的生物标志物来预测SR,并指导BE的新治疗策略.
主要方法:
- 对2229名高风险男性退伍军人进行了为期27年的前性纵向研究,追踪结直肠和食道瘤,包括BE和SR.
- 在BE粘膜中对抗原和炎症变化的横截面分析和先天免疫系统 (InImS) 标记物的调查.
主要成果:
- 在46名BE患者中,10名 (21.7%) 患有SR.
- SR与年龄较小,血小板数量较低,直肠p87升高和InImS FEREFF比率降低 (费里:p87结肠清洗) 有显著的关联.
- 确定了一系列瘤生物标志物,其中InImS标志物显示出干预的潜力.
结论:
- 观察到巴雷特食道的自发回归,并与特定的临床和免疫因素有关.
- 天生的免疫系统标志物可能易受干预,可能促进SR,并为治疗食道瘤提供新的途径.
相关概念视频
Barrett Esophagus-I: Introduction
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Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
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Barrett Esophagus-II: Clinical Manifestations and Management
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Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
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Esophageal Strictures-I: Introduction
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Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
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The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
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Gastroesophageal Reflux Disease II: Clinical Features and Management
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Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
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GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
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Esophageal Strictures-II: Clinical Features and Management
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Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
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Gastroesophageal Reflux Disease I: Meaning and Pathophysiology
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Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
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