塞菲德罗科尔用于治疗由VIM型产生格拉姆阴性细菌的感染
Cristina Kirkegaard-Biosca1,2, Ester Del Barrio-Tofiño3, Miguel Villamarín1
1Infectious Diseases Department, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain.
Antibiotics (Basel, Switzerland)
|September 28, 2024
概括
塞菲德罗科尔对治疗难以产生VIM类型酶的格拉姆阴性细菌 (GNB) 感染具有前景. 虽然15%的人经历了临床失败和27%的30天死亡率,但结果表明它可能是一个可行的单一治疗选择.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 产生VIM类型的グラム阴性细菌 (GNB) 感染带来了重大治疗挑战.
- 对于这些多药耐药生物体,有效的治疗选择有限.
研究的目的:
- 评估Cefiderocol在治疗VIM型产生的GNB感染中的临床有效性和安全性.
- 评估结果,包括临床失败和全因死亡率.
主要方法:
- 对34名接受Cefiderocol治疗的患者进行了回顾性单中心研究.
- 这些感染包括Pseudomonas spp.,Enterobacterales和Achromobacter sp.等.
- 主要结局:14日临床失败和30日全因死亡率.
主要成果:
- 15%的患者在第14天经历了临床失败.
- 30天所有原因的死亡率为27% (9/34).
- 在持久或复发性感染的1/7个病例中,发生了对Cefiderocol的耐药性.
结论:
- 塞菲德罗科尔可以被视为VIM型产生GNB感染的单疗法选择.
- 仔细的源控制和对电阻的监测至关重要.
- 需要进一步的前性研究来证实这些发现.
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