叶绿素对抗Streptococcus mutans的抗菌和抗生物膜潜力 在体外和在体内
Seemrose Khan1, Ihtisham Ul Haq2,3,4, Imran Ali5
1Department of Microbiology, Kohat University of Science & Technology, Kohat 26000, Pakistan.
Antibiotics (Basel, Switzerland)
|September 28, 2024
概括
菜中的叶绿素表现出强烈的抗菌和抗菌膜作用,对抗菌突变菌 (Streptococcus mutans),这是导致牙的主要原因. 其有利的安全性概况表明,它有可能作为预防牙的治疗剂.
科学领域:
- 微生物学 微生物学
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
背景情况:
- 牙损是一个主要的全球健康问题,由Streptococcus mutans生物膜引起.
- Streptococcus mutans 的致病性与生物膜形成有关.
- 据估计,全球约有25亿人受到牙损伤的影响.
研究的目的:
- 评估来自Spinacia oleracea的罗菲林对Streptococcus mutans的抗菌和抗菌膜潜力.
- 通过in silico研究来研究素的抗菌机制.
- 评估的药理动力学特性和安全性.
主要方法:
- 使用阿加井扩散方法评估了抗菌活性.
- 对抗生物膜的有效性被评估为对抗S. mutans分离物.
- 进行了素与S. mutans AgI/II蛋白质的分子对接.
- 进行了吸附,分布,新陈代谢,分泌和毒性 (ADMET) 分析.
主要成果:
- 叶绿素提取物在S. mutans分离物中表现出显著的敏感性,抑制区范围为32至41毫米.
- 叶绿素降低了S. mutans分离物的生物膜强度,从强到中度或弱.
- 里埃变换红外光谱仪 (FTIR) 分析表明,氨酸对细胞外聚合物质 (EPS) 功能组的影响.
- 分子对接揭示了叶绿素与S. mutans AgI/II蛋白结合,这对于生物膜启动至关重要.
- 对ADMET的分析表明,罗菲林具有有利的药理动力学特性.
结论:
- 叶绿素表现出有希望的抗菌和抗菌膜特性,可以对抗生物膜形成的S. mutans.
- 叶绿素的安全概况支持其作为治疗牙损伤的治疗剂的潜力.
- 对叶绿素的治疗用途进行进一步的研究是有必要的.
关键词:
在ADMET分析中,分析了ADMET.突变型链球菌 (Streptococcus mutans) 是一种突变型链球菌.它具有抗菌活性,具有抗菌活性.生物膜是一种生物膜.叶绿素 (chlorophyllin) 是一种含有叶绿素的成分.牙腐烂是指牙的腐烂.蛋白质的对接方式更多相关视频
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