在丹麦,芬兰,挪威和瑞典,慢性淋巴细胞白血病的诊断和生存之间的复杂关系
Kari Hemminki1,2, Frantisek Zitricky1, Asta Försti3,4
1Biomedical Center, Faculty of Medicine, Charles University, 323 00 Pilsen, Czech Republic.
Cancers
|September 28, 2024
概括
50年来,慢性淋巴细胞白血病 (CLL) 的生存率在所有年龄组都显著提高. 最近的数据显示,5年生存率很高,甚至在老年患者中接近90%,这表明CLL治疗的进展.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 慢性淋巴细胞白血病 (CLL) 是一种异质的血液性恶性瘤.
- 对CLL的治疗策略已经发展,影响了患者的治疗结果.
- 诊断时的年龄是影响治疗决策和生存的关键因素.
研究的目的:
- 分析慢性淋巴细胞白血病 (CLL) 在50年至2020年代的年龄特定生存趋势.
- 调查诊断年龄对CLL患者生存结果的影响.
- 为了比较北欧国家和美国之间的生存趋势.
主要方法:
- 使用来自NORDCAN数据库 (丹麦,芬兰,挪威,瑞典) 的1年和5年相对生存数据.
- 分析了CLL的发病率和死亡率趋势,因为其呈现方式可变.
- 纳入的美国SEER数据用于比较分析.
主要成果:
- 从1972-76年到2017-21年,CLL的特定年龄生存差异显著减少.
- 在丹麦和瑞典,年轻患者的五年生存率超过90%,老年患者 (80-89岁) 的高达90%.
- 丹麦报告了高的5年总生存率 (92.4%的男性,96.3%的女性),超过了美国的数据.
结论:
- 丹麦CLL存活率数据可能代表全球顶级数据,在老年人群中有可能进一步改善.
- 国际比较需要考虑发病率,丹麦和挪威的发病率很高.
- 芬兰80-89岁患者的生存率较低表明诊断延迟的可能性,这需要国家审查.
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