乳腺癌诊断后的不良产科结果:德国的一项观察数据库研究
Anna Sophie Scholz1, Alexandra von Au1, Raphael Gutsfeld2
1Department of Gynecology and Obstetrics, Heidelberg University Hospital, 69120 Heidelberg, Germany.
Cancers
|September 28, 2024
概括
乳腺癌 (BC) 后的怀孕是可行的,没有过早分娩或妊娠糖尿病的风险增加. 然而,在诊断后不到两年的分娩会增加怀孕年龄小的婴儿和低出生体重婴儿的风险.
科学领域:
- 在瘤学瘤学.
- 产科和妇科 产科和妇科
- 生殖医学 生殖医学
背景情况:
- 乳腺癌 (BC) 诊断可以影响未来的怀孕和分娩.
- 了解BC幸存者的产科结果对于生殖咨询至关重要.
研究的目的:
- 分析先前乳腺癌对诊断后怀孕中产科结果的影响.
- 为了比较BC幸存者和年龄匹配的对照之间的结果.
主要方法:
- 德国南部 (2010-2020年) 保险索赔数据的回顾性分析.
- 确定了74名乳腺癌幸存者与随后的分娩.
- 将幸存者与222名年龄匹配的对照进行了比较,分娩时的年龄与频率进行了匹配.
主要成果:
- 内分泌疗法使用与降低出生概率 (HR 0.36) 有关.
- 在BC幸存者中,早产,低出生体重 (LBW),妊娠糖尿病,高血压疾病或剖腹产没有显著增加.
- 在BC幸存者中,胎儿对于妊娠年龄小 (SGA) 的风险更高 (OR 3.24).
- 诊断后2年以下的分娩增加了SGA (OR 5.73) 和LBW (OR 4.57) 的风险.
结论:
- 乳腺癌后的怀孕通常与有利的产科结果有关.
- 出生时间至关重要;诊断后<2年增加了SGA和LBW的风险.
- 这些发现支持在BC之后为妇女提供怀孕咨询,强调分娩时间.
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