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功能性MRI评估与阅读相关的大脑活动模式在脑髓母细胞瘤幸存者的功能性MRI评估

Josue L Dalboni da Rocha¹, Ping Zou Stinnett¹, Matthew A Scoggins²

¹Department of Diagnostic Imaging, St. Jude Children Research's Hospital, Memphis, TN 38105, USA.

|September 28, 2024

概括

童年脑髓母细胞瘤幸存者表现出不断发展的大脑活动差异,随着时间的推移影响阅读能力. 早期干预对于解决这些神经功能变化和改善认知结果至关重要.

科学领域:

神经科学是一个神经科学.
儿科瘤学儿科瘤学
认知科学认知科学

背景情况:

骨髓母细胞瘤治疗改善了生存率,但可能导致长期的认知缺陷,特别是在阅读方面.
双赤字理论认为阅读障碍源于语音意识或快速视觉命名的缺陷.

研究的目的:

与对照人群相比,研究与脑髓母细胞瘤幸存者的读数相关的纵向神经功能变化.
为了确定癌症治疗如何影响随着时间的推移与阅读能力相关的脑功能.

主要方法:

纵向功能性MRI (fMRI) 在快速自动化命名任务期间,每年三次访问.
支持矢量机器分类来分析fMRI数据和大脑活动模式.
脑髓母细胞瘤幸存者与健康对照者的比较.

主要成果:

随着时间的推移,幸存者和对照者之间脑活动模式的逐渐分歧被观察到.
确定了涉及视觉处理和正写识别的腹部视觉通路的大脑区域的变化.
这些神经功能变化与语音意识,阅读流性和词攻击方面的缺陷相关.

结论:

癌症治疗对阅读至关重要的神经功能通路产生动态的,延迟的影响.
早期识别和干预对于缓解脑髓母细胞瘤幸存者的认知缺陷至关重要.

关键词:

大脑瘤是个大脑瘤认知障碍是一种认知障碍.功能磁力共振成像 (fMRI) 是一种脑髓母细胞瘤是什么意思快速自动化命名方式阅读阅读阅读阅读阅读阅读阅读

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