循环的肠道微生物衍生的代谢物与肝细胞癌有关
Rakhee Banerjee1,2, Chase J Wehrle3, Zeneng Wang2,4
1Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Biomedicines
|September 28, 2024
概括
肠道微生物群代谢物的血水平,包括三甲基胺N-氧化物 (TMAO) 途径化合物,在肝细胞癌 (HCC) 患者中显著改变. 这些代谢变化可能为早期HCC检测提供潜在的非侵入性生物标志物.
科学领域:
- 胃肠病学和肝病学
- 在瘤学瘤学.
- 微生物组研究 微生物组研究
背景情况:
- 肝细胞癌 (HCC) 是全球癌症死亡的主要原因.
- 肠道微生物组在HCC的发展和进展中起着重要作用.
- 肠道微生物衍生代谢物是早期检测HCC的潜在非侵入性生物标志物.
研究的目的:
- 为了评估HCC患者和健康对照者之间的肠道微生物群衍生代谢物的血度差异.
- 为了确定特定的代谢物,可以作为早期HCC检测的潜在的非侵入性指数.
主要方法:
- 一项涉及41名HCC患者和96名健康对照者的比较研究.
- 分析肠道微生物群衍生循环代谢物的血度.
- 使用二进制物流回归和层次聚类进行代谢物概况的统计分析.
主要成果:
- 患有HCC的患者显示TMA相关代谢物的血度显著更高,包括胆,贝他因,卡尼丁,TMA和TMAO.
- 在HCC患者中观察到高水平的P-cresol糖化物,英多尔乳酸,5-基英多利酸和4-基酸.
- 代谢物分析成功地将HCC患者与健康对照区分开来,但不区分患有肝硬化或没有肝硬化的HCC患者.
结论:
- 与健康个体相比,肠道微生物群衍生代谢物在HCC患者中异常丰富.
- 在HCC中,TMAO通路的干扰特别明显,需要进一步调查.
- 这些发现表明肠道微生物群代谢物在HCC管理中的潜在诊断和治疗应用.
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