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Updated: Jun 11, 2025

An HS-MRM Assay for the Quantification of Host-cell Proteins in Protein Biopharmaceuticals by Liquid Chromatography Ion Mobility QTOF Mass Spectrometry
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在炎症性肠病中使用infliximab:在临床环境中利用基于生理学的药物动力学建模

Zvonimir Petric1, João Gonçalves2, Paulo Paixão1

  • 1Department of Pharmacological Sciences, Research Institute for Medicines, Faculty of Pharmacy, University of Lisbon, 1649-004 Lisbon, Portugal.

Biomedicines
|September 28, 2024
PubMed
概括

基于生理学的药物动力学建模表明,120毫克皮下注射的因弗利克西马布剂量可能需要在患有炎症性肠病 (IBD) 的较重成年人中进行调整. 对于IBD治疗,还提供了儿童用剂量建议.

关键词:
临床药理学临床药理学炎症性肠病 (IBD) 是一种炎症性肠病.这就是Infliximab的价值.基于生理学的药理动力学 (PBPK) 建模.

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