探索生活方式与男性表观遗传生物学年龄之间的关系
Te-Min Ke1, Artitaya Lophatananon1, Kenneth R Muir1
1Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PT, UK.
Biomedicines
|September 28, 2024
概括
生活方式的选择会影响生物年龄. 高和脂肪,卡路里和BMI加速衰老,而维生素D和健康生活方式指数 (HLI) 减缓它,为疾病预防提供了洞察力.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 老年学是一门学科.
- 营养科学 营养科学
背景情况:
- 基因甲基化作为一个验证的生物标志物用于生物年龄.
- 生物年龄是未来健康结果的预测因素,包括发病率和死亡率.
研究的目的:
- 研究生活方式模式与英国男性表观遗传变化之间的关联.
- 探索特定的饮食因素和生活方式选择如何影响生物衰老标志物.
主要方法:
- 利用五个不同的生物年龄钟来评估表观遗传标记.
- 用斯皮尔曼相关性,皮尔森相关性和单变线性回归来进行数据分析.
- 预期研究设计涉及221名男性参与者.
主要成果:
- 加快的生物衰老与更高的和脂肪摄入量,每日总热量和身体质量指数 (BMI) 相相关.
- 减缓生物衰老与增加维生素D摄入量和更高的健康生活方式指数 (HLI) 相关.
结论:
- 特定的生活方式因素显著影响生物衰老的速度.
- 研究结果表明,生活方式干预,特别是饮食和健康习惯,在疾病预防策略中具有潜力.
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