1型糖尿病患者的葡萄糖变化:与体重,身体成分和胰岛素敏感性的关联
Julia F Semenova1, Anton Yu Yushin1, Anton I Korbut1
1Laboratory of Endocrinology, Research Institute of Clinical and Experimental Lymphology-Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (RICEL-Branch of IC&G SB RAS), 630060 Novosibirsk, Russia.
Biomedicines
|September 28, 2024
概括
在1型糖尿病 (T1D) 中,超重和肥胖与低血糖和降低葡萄糖可变性有关. 肥胖会影响葡萄糖的控制,可能是通过胰岛素抵抗.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 糖尿病研究研究 糖尿病研究
背景情况:
- 在1型糖尿病 (T1D) 人群中,超重和肥胖的患病率增加.
- 我们对脂肪积累如何影响T1D中的葡萄糖动态的理解有限.
研究的目的:
- 评估T1D患者的持续血糖监测 (CGM) 参数,基于体重,组成和胰岛素敏感性.
- 研究T1D中脂肪和葡萄糖控制之间的关系.
主要方法:
- 对547名T1D患者 (238名超重/肥胖) 的CGM数据 (TIR,TAR,TBR,GV) 的分析.
- 用DXA评估的身体组成;用eGDR估计的胰岛素敏感性.
- 在正常体重和超重/肥胖个体之间的葡萄糖动态的比较.
主要成果:
- 超重/肥胖的T1D患者表现出较低的TBR,GV和较少的低血糖期.
- 在男性中,中心脂肪与较低的TIR,较高的TAR和减少的GV相关.
- 在女性中,膝关节脂肪质量与较低的TIR和较高的TAR有关.
- 在两种性别中,eGDR积极预测TIR,负面预测TAR,TBR和GV.
结论:
- 在T1D中,肥胖与降低低血糖风险,超过范围的时间和降低葡萄糖可变性有关.
- 这些葡萄糖动态可能受到胰岛素抵抗的影响.
- 身体成分和胰岛素敏感性是管理T1D葡萄糖控制的关键因素.
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