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一种创新的多成分配方在通过影响氧化和炎症途径来抵消人类皮肤纤维细胞衰老方面的有效性

Francesca Rosaria Augello¹, Francesca Lombardi¹, Alessia Ciafarone¹

¹Department of Life, Health and Environmental Sciences, University of L'Aquila, 67100 L'Aquila, Italy.

|September 28, 2024

概括

一种新的KARISMA Rh原蛋白FACE配方通过清除自由基和增强抗氧化防御来对抗皮肤衰老. 它通过调节关键细胞通路来减少炎症和衰老标志物,支持皮肤再生.

科学领域:

皮肤病学和细胞生物学
衰老的生物化学衰老的生物化学
化品科学化品科学

背景情况:

皮肤衰老与反应性氧物种 (ROS) 积累有关.
氧化应激会触发细胞衰老和炎症过程.
了解抗衰老配方的机制至关重要.

研究的目的:

在老化的人体皮肤纤维细胞 (HDFs) 上研究多组分配方 (K) 的机制.
评估K的直接自由基清除作用和抗氧化系统的调制.
评估K对炎症途径和衰老标志物的影响.

主要方法:

评估了自由基清除能力和抗氧化酶活性 (SOD,CAT).
通过Western blot分析了核因子E2相关因子2 (Nrf2) 和核因子kappa-B (NF-κB) 的水平.
测量了促炎性细胞因子,矩阵金属蛋白酶 (MMPs) 和高级糖化最终产物 (AGEs).

主要成果:

K配方证明了对压力诱导的衰老的剂量依赖的对抗作用.
增加抗氧化酶活动 (SOD,CAT) 和-Nrf2 (p-Nrf2) 表达.
减少了促炎性细胞因子,MMP和AGE,与-NF-κB (p-NF-κB) 水平降低有关.

结论:

K配方具有直接的清除效果,并增强内源抗氧化系统.
它通过降低p-NF-κB的调节和升高Nrf2激活来调节炎症途径.
该配方显示了治疗皮肤衰老的修复和再生潜力.

关键词:

年龄 AGE 年龄 AGE 在 NF-κBB 中.Nrf2 没有任何问题.抗氧化剂系统抗氧化剂系统皮肤纤维细胞.清除自由基 - 清除自由基 - 清除自由基矩阵金属蛋白质酶是一种金属蛋白质.这是一种多元组件配方.有助于炎症的细胞因子.皮肤老化皮肤老化

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