癌症免疫治疗对生育能力的影响:专注于血液恶性瘤
Santino Caserta1, Gabriella Cancemi1, Giuseppe Murdaca2,3
1Hematology Unit, Department of Human Pathology in Adulthood and Childhood "Gaetano Barresi", University of Messina, via Consolare Valeria, 98125 Messina, Italy.
Biomedicines
|September 28, 2024
概括
免疫疗法可以改善癌症的存活率,但可以通过改变免疫反应并引起炎症来损害生育能力. 对于接受这些治疗的患者来说,保持生育能力至关重要.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生殖医学 生殖医学
背景情况:
- 癌症管理在免疫疗法方面取得了进展,改善了生存率.
- 免疫疗法可能会导致长期的副作用,包括性腺毒性和生育能力受损.
- 人们越来越担心新型癌症治疗对男性和女性生育能力的影响.
研究的目的:
- 审查免疫治疗对血液癌症患者生育能力的影响.
- 分析免疫疗法影响生殖健康的机制.
- 为了强调在这种患者群体中保持生育能力的重要性.
主要方法:
- 文献评论专注于免疫疗法和生育能力.
- 对检查影响性腺体的免疫相关不良事件的研究进行分析.
- 检查涉及细胞因子和特定免疫通路 (例如AMPK/mTOR) 的机制.
主要成果:
- 免疫疗法可以导致高水平的促炎细胞因子和与免疫相关的不良事件影响生育能力.
- 在男性中,免疫检查点抑制剂可能会导致低精子发生和非精子发生.
- 在女性中,已记录过卵巢储备损伤,重复流产和植入失败.
结论:
- 免疫疗法对男性和女性的生育能力构成重大风险,特别是在血液癌症患者中.
- 对于接受免疫治疗的人来说,生育能力保护方法是必不可少的.
- 需要进一步的研究,以了解免疫治疗对生育能力的影响,并标准化保存方案.
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