结肠囊内镜在炎症性肠病中的诊断准确性-系统性审查和元分析
Ian Io Lei1,2, Camilla Thorndal3, Muhammad Shoaib Manzoor4
1Institute of Precision Diagnostics & Translational Medicine, University Hospital of Coventry and Warwickshire, Clifford Bridge Rd, Coventry CV2 2DX, UK.
Diagnostics (Basel, Switzerland)
|September 28, 2024
概括
结肠囊内镜 (CCE) 能够有效地诊断炎症性肠道疾病,如性结肠炎和克罗恩病,对这两种疾病都有很高的敏感性. 虽然存在挑战,但CCE对这些炎症性肠道疾病具有很强的诊断准确性.
科学领域:
- 胃肠病学 胃肠病学
- 医疗成像医学成像
- 诊断的准确性 诊断的准确性
背景情况:
- 结肠囊内镜 (CCE) 的使用在COVID-19后的下肠道检查中增加了.
- 现有的审查侧重于聚体检测,留下了结肠炎症诊断证据的空白.
- 需要进行系统审查和元分析来评估CCE对炎症性肠病 (IBD) 的准确性.
研究的目的:
- 评估CCE对结肠炎的诊断准确性,特别是性结肠炎 (UC) 和克罗恩病 (CD).
- 为了将CCE性能与光学内镜进行比较,作为黄金标准参考.
主要方法:
- 系统地搜索EMBASE,MEDLINE,PubMed中央和科克兰图书馆.
- 包括23项涉及1353名患者的研究,比较CCE和光学内镜.
- 用于对诊断准确性的元分析的双变随机效应模型.
主要成果:
- 对于UC (92%) 和CD (92%),CCE表现出高的聚合灵敏度.
- 联合UC的特异性为71%,CD的特异性为88%.
- 整体IBD诊断准确度显示,综合灵敏度为90%,特异性为76%,AUC为0.92.
结论:
- CCE在诊断炎症性肠病方面表现良好,对UC和克罗恩病具有很高的敏感性.
- 对于克罗恩病诊断的高特异性被注意到.
- 建议进行进一步的研究,以评估CCE对其他结肠炎症状况的准确性.
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