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[18F]FDG PET/CT整合评估肺癌免疫疗法:临床医生的实际方法

Juliette Brezun¹, Nicolas Aide², Evelyne Peroux³

¹Department of Medical Oncology and Clinical Research Unit, Military Hospital Bégin, 94160 Saint-Mandé, France.

Diagnostics (Basel, Switzerland)

|September 28, 2024

概括

免疫检查点抑制剂可以改善肺癌的生存率,但需要新的方法来评估治疗反应. 像iRECIST和PET/CT成像等新标准有助于管理复杂的反应,改善患者的治疗结果.

科学领域:

在瘤学瘤学.
放射学放射学是一门学科.
核医学就是核医学.

背景情况:

免疫检查点抑制剂 (ICI) 已经改变了肺癌的治疗方法,提高了生存率.
评估对免疫疗法的治疗反应是具有挑战性的,因为非标准的模式,如伪进展和超进展.
传统的RECIST 1.1标准可能无法完全捕捉到这些复杂的反应.

研究的目的:

审查肺癌免疫疗法的新响应评估标准.
要突出成像的作用,包括 [18F]FDG PET/CT,在评估治疗反应.
强调多学科方法对最佳患者管理的重要性.

主要方法:

讨论基于RECIST的响应评估的iRECIST和imRECIST标准.
对 [18F]FDG PET/CT 的代谢反应标准的审查,包括 PERCIMT,imPERCIST 和 iPERCIST.
强调将成像发现纳入临床决策.

主要成果:

新的标准 (iRECIST,imRECIST,PERCIMT,imPERCIST,iPERCIST) 可以更好地评估肺癌免疫疗法反应.
[18F]FDG PET/CT对于检测伪进展和其他非传统反应有价值.
多学科合作是解释复杂反应模式的关键.

结论:

先进的成像和更新的标准对于准确评估接受免疫治疗的肺癌患者至关重要.
有效的解释需要瘤学家,放射学家和核医学专家之间的合作.
本综述为临床医生在免疫疗法时代管理肺癌提供了指导.

关键词:

[18F]FDG PET/CT成像技术使用免疫检查点抑制剂免疫检查点抑制剂肺癌是一种肺癌.治疗反应评估治疗反应评估.

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