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患有急性淋巴细胞白血病的儿童的感染
Silvije Šegulja1, Klara Vranešević2, Ana Đorđević3
1Department of Clinical Medical Studies, Faculty of Health Studies, University of Rijeka, 51000 Rijeka, Croatia.
患有急性淋巴细胞白血病 (ALL) 的儿童经常感染,通常是在密集治疗阶段. 及时使用抗生素和监测对于减少儿科ALL患者感染相关并发症和死亡率至关重要.
科学领域:
- 儿科瘤学 儿科瘤学
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
背景情况:
- 在接受急性淋巴细胞白血病 (ALL) 治疗的儿童中,感染是常见的和危及生命的并发症.
- 了解这些感染的流行病学,临床和微生物学方面对于有效管理至关重要.
研究的目的:
- 确定患有ALL的儿科患者感染的流行病学,临床和微生物学特征.
- 确定影响感染相关发病率和死亡率的关键因素,在这个脆弱的人群中.
主要方法:
- 在2015年至2020年期间对23名患有ALL的儿科患者进行了回顾性研究.
- 分析了104个传染病发作,重点关注感染部位,致病原体,治疗和结果.
主要成果:
- 传染病发作 (IE) 频繁 (平均每患者4.5),特别是在密集治疗期间,并与中性质减退相关.
- 呼吸道感染最常见,其中细菌病原体占主导地位.
- 经常采用抗菌疗法修改和支持性护理 (G-CSF,IVIG);没有观察到与感染有关的死亡率.
结论:
- 儿科ALL患者面临着很高的传染性发作负担.
- 有效的管理策略包括密切监测,迅速实证抗生素治疗发烧性中性质衰竭,及时调整抗菌疗法.
- 这些干预措施对于减少ALL儿童感染相关的发病率和死亡率至关重要.
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