评估不同吸入剂对卵巢与高温腹腔内化学疗法的影响:一项实验研究
Özlem Şen1, Esra Aslan2, Dilek Kalaycı3
1Department of Anesthesiology and Reanimation, Trabzon Kanuni Training and Research Hospital, Trabzon 61250, Turkey.
Medicina (Kaunas, Lithuania)
|September 28, 2024
概括
使用西斯普拉丁的高热性腹腔内化疗会损害卵巢储备. 在HIPEC手术过程中,sevoflurane麻醉可以通过减少细胞亡和保持卵泡数量来减轻这种西斯普拉丁诱导的卵巢毒性.
科学领域:
- 在瘤学瘤学.
- 生殖生物学 生殖生物学
- 麻醉学 麻醉学
背景情况:
- 西斯是一种化疗剂,用于高热性腹腔内化疗 (HIPEC).
- 齐斯普拉丁诱导的性腺毒性会导致卵巢储备枯竭和过早的卵巢功能不充分.
- 超热和麻醉选择对西斯普拉丁诱导的卵巢毒性的影响需要研究.
研究的目的:
- 为了研究超热症对西斯普拉丁诱导的卵巢毒性的影响.
- 为了确定是否sevoflurane或desflurane麻醉可以减少卵巢毒性在HIPEC程序.
主要方法:
- 新西兰子接受了HIPEC与西斯,有或没有sevoflurane或desflurane麻醉.
- 卵巢组织使用血素和氨酸染色和免疫组织化学分析进行了分析.
- 评估了亡和毛囊数量的关键标志物.
主要成果:
- 西斯-HIPEC显著降低了主要卵泡的数量.
- 塞沃隆麻醉降低了西斯普拉丁诱导的Bax和p53表达的增加,并增加了Bcl-2表达.
- 与单独使用HIPEC相比,sevoflurane和desflurane都降低了p53的表达.
结论:
- 在手术期间使用西斯普拉丁的HIPEC会导致卵巢损伤.
- 在HIPEC期间,sevoflurane麻醉似乎是减轻卵巢储备损伤和亡的更合适选择.
- 建议进行进一步的临床和实验研究以验证这些发现.
关键词:
头 - - 头是一个头.在Caspase 3阶段.西斯普拉丁 (cisplatin) 是一种制剂.德斯弗鲁兰是什么意思 德斯弗鲁兰是什么意思卵巢 卵巢是一个卵巢.在 p53 里,p53 是一个 p53 号码.七伏氨酸是什么意思更多相关视频
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