系统性炎症指数对预测结肠直肠癌早期术后并发症的价值
Irina Shevchenko1,2, Catalin Cicerone Grigorescu3, Dragos Serban1,2
1Faculty of Medicine, Carol Davila University of Medicine and Pharmacy Bucharest, 020021 Bucharest, Romania.
Medicina (Kaunas, Lithuania)
|September 28, 2024
概括
系统性炎症指数如NLR,PLR,SII和MLR可以预测结直肠癌患者的早期术后结果. 这些廉价的标记物对紧急和选择性手术都很有前途.
科学领域:
- 在瘤学瘤学.
- 外科胃肠道外科手术
- 血液学 血液学 血液学
背景情况:
- 系统性炎症指数在各种疾病中被探索为预测价值,但它们在结直肠癌 (CRC) 中的作用需要进一步调查.
- 了解手术前和后的炎症标志物动态对于预测CRC患者的结果至关重要.
研究的目的:
- 在结肠直肠癌患者中调查前和术后的中性细胞与淋巴细胞比率 (NLR),血小板与淋巴细胞比率 (PLR),全身免疫炎症指数 (SII) 和单细胞与淋巴细胞比率 (MLR) 的动态.
- 评估这些系统性炎症指数在急诊和选择性CRC手术中对早期术后结果的预测价值.
主要方法:
- 一项为期2年的回顾性队列研究,涉及200名患有结直肠腺癌的患者.
- 从手术前和手术后的第1天和第6天的全血细胞计数计算系统性炎症指数 (NLR,PLR,SII,MLR).
- 通过紧急与选择性手术呈现分层分析数据,将炎症标志物与术后结果关联起来.
主要成果:
- 与选择性患者相比,紧急手术患者在手术前和手术后的白细胞 (WBC),中性细胞,NLR和SII值较高.
- 术后住院与术前和术后的NLR,PLR,SII和MLR值有显著的相关性.
- 术后第一天的NLR和SII显示出强大的败血症预测价值,而PLR和贫血预测严重并发症 (Clavien-Dindo等级≥3) 和选择性病例的重新干预.
结论:
- 廉价且易于计算的全身炎症生物标志物 (NLR,PLR,SII,MLR) 是预测结直肠癌早期术后结果的宝贵工具.
- 这些标记可以帮助风险分层和管理规划,用于紧急和选择性结直肠癌手术.
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