·维勒布兰德因子抗原,炎症的生物标志物,以及重建性手术中的微血管血栓
Rihards Peteris Rocans1,2, Janis Zarins3,4, Evita Bine1
1Intensive Care Clinic, Riga East University Hospital, Hipokrata Street 2, LV-1079 Riga, Latvia.
Journal of clinical medicine
|September 28, 2024
概括
手术前的·威尔布兰德因子抗原 (VWF:Ag) 水平预测了微血管手术并发症. 较高的VWF:Ag表明风险增加,可能与慢性炎症有关.
科学领域:
- 血管外科 血管外科
- 生物标志物 生物标志物
- 炎症 炎症是一种炎症.
背景情况:
- 微血管手术是一种标准的重建技术.
- ·维莱布兰德因子抗原 (VWF:Ag) 在片并发症中的作用尚不清楚.
- 了解VWF:Ag的预测潜力对于患者的治疗结果至关重要.
研究的目的:
- 为了评估手术前VWF:Ag对微血管并发症的预测价值.
- 探索VWF:Ag与慢性炎症标志物之间的关联.
主要方法:
- 对88名接受微血管手术的患者进行前性队列研究.
- 在手术前的血中测量了VWF:Ag,白蛋白,中性粒细胞与淋巴细胞的比率 (NLR),介质素-6和纤维素原.
- 进行了包括回归在内的统计分析,以评估VWF:Ag的预测作用.
主要成果:
- 整体并发症率为27.3%,其中11.4%是真正的损失.
- 在患有真正片损失的患者 (217.94 IU/dL) 和没有并发症的患者 (114.14 IU/dL) 中,观察到显著更高的VWF:Ag水平.
- 增加的VWF:Ag与增加的纤维素素,C反应蛋白,互白素-6和NLR相关.
结论:
- 手术前的VWF:Ag度是预测微血管并发症的潜在生物标志物.
- VWF:Ag水平与炎症标志物有关,这表明炎症和片失败之间存在联系.
- 测量VWF:Ag可能有助于识别患有片并发症风险较高的患者.
相关概念视频
01:22Formation of the Platelet Plug
5.1K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
5.1K
01:16Clot Retraction and Fibrinolysis
4.7K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
4.7K
01:20Extrinsic and Intrinsic Pathways of Hemostasis
6.3K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
6.3K
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
636
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
636